Dr Andrew Evans
Lecturer/Senior Lecturer in Pharmacology - School of Pharmacy and Biomolecular Sciences
Tel: 0151 231 2145
Email: a.r.evans@ljmu.ac.uk
Professional Membership
The British Association for Cancer Research, 2003-present.
Research interests
Tumour hypoxia
Current Research Students and Funding
1st supervisor for MPhil industrial student Kathryn Mason. Project title “The development of ICH compliant methodologies to determine the physical and biological stability of the monoclonal antibody drug bevacizumab (Avastin) during storage in ready-to-use syringes and vials”. (Funded by the Quality Control North West, Pharmacy Practice Unit, Liverpool and by the Ascetic Unit, NHS Royal Liverpool University Hospital, Liverpool).
2nd supervisor for PhD student Victoria Bates. Project title “Influence of Glut-1 on response to bioreductive drugs in bladder cancer”. (Funded by European Union Framework VI).
2nd supervisor for PhD student Katarzyna Bloch. Project title “An integrated genomics and metabonomics approach to developing in vitro methods for assessing the carcinogenic potential of compounds to the kidney”. (Part of a European carcinogenomics project funded by European Union).
Grant holder
Grant title “Angiogenesis & tumour hypoxia”. (Funded by the Royal Manchester Children’s Hospital, Manchester).
Collaborative Research Links
Cancer Research Unit, University of Bradford, UK (Dr. Roger Phillips) in vivo tumour biology of hypoxia and glucose transport and translational research in bladder cancer
Royal Manchester Children’s Hospital, Department of Oncology, Manchester, UK (Dr. Edward Estlin) Translational research in children’s cancer, hypoxia, angiogenesis and glucose transport and influence on chemosensitivity and survival.
Recent Publications (included in RAE(2008))
Evans,A., Bates, V., Troy, H., Hewitt, S., Holbeck, S., Chung, Y-L., Phillips., R., Stubbs, M., Griffiths, J., Airley, R. Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies (2008). Cancer Chemother. Pharmacol., 61, 377-393.
Airley, R., Phillips, RM., Evans, A., Double, J., Burger, AM., Feibig, HH., West, CML., Stratford, IJ. Hypoxia-regulated Glucose Transporter Glut-1 may Influence Chemosensitivity to some Alkylating Agents: Results of EORTC (First Translational Award) Study of the Relevance of Tumour Hypoxia to the Outcome of Chemotherapy in Human Tumour-Derived Xenografts. (2005). Int. J. Oncol., 26, 1477-1484.
